Peppas, Nicholas A. Sc.D.

Fletcher Stuckey Pratt Chair in Engineering
Professor of Chemical Engineering, Biomedical Engineering and Pharmacy
Chair of the Department of Biomedical EngineeringDr. Nicholas Peppas

Office: CPE 3.466 Mailing Address:
Phone: 512-471-6644 The University of Texas at Austin
Fax: 512-471-8227 Department of Chemical Engineering
Email: peppas@che.utexas.edu 200 E Dean Keeton St. Stop C0400
UT Mail: C0400 Austin, TX 78712-1589

Research Areas: Advanced Materials, Polymers & Nanotechnology                                                  and Biotechnology

Research Group Website                         

Research Presentation for Prospective Graduate Students

Educational Qualifications

Sc. D., Massachusetts Institute of Technology  (1973)
Dipl. Eng., National Technical University of Athens, Greece  (1971)
Doc. Hon. Causa, University of Ghent, Belgium (1999)
Pharm. D. Hon. Causa, University of Parma, Italy (1999)
Doc. Hon. Causa, University of Athens, Greece (2000)

Courses Taught

ChE 322 (U): “Chemical Engineering Thermodynamics”
ChE 355 (U): “Introduction to Polymer Science”
ChE 372 (U): “Kinetics and Reaction Engineering”
ChE 379/384 (U/G): “Polymerization Kinetics and Reaction Engineering
ChE 384 (G): “Advances in Biomedical Engineering”
ChE 387M (G): “Mass Transfer”
BME 380J.2 (G): “Quantitative Physiology”
BME 385J (G): “Fields, Forces and Flows in Cellular and Physiological Systems”
BME 385J.4 (G): “Advances in Biomaterials Science and Engineering”
BME 385J (G) and ChE 384 (G): “Bionanotechnology”

Focus

Polymer physics; Polymerization reaction engineering; Diffusion in polymers; Controlled drug delivery; Biomedical engineering; Biomaterials; Molecular modeling of protein structures in contact with biomaterials and tissues; Modeling of biomedical devices; Bionanotechnology; Molecular recognition processes.

Research

Our research contributions have been in several areas of drug delivery, biomaterials, biomolecular engineering, mass transfer, kinetics and reaction engineering, polymers and biomedical engineering. The multidisciplinary approach of his research in biomolecular engineering blends modern molecular and cellular biology with engineering to generate next-generation systems and devices, including bioMEMS with enhanced applicability, reliability, functionality, and longevity. The fundamental studies of his group have provided valuable results on biomaterials design and development.

Our group is known for our work on the preparation, characterization and evaluation of the behavior of compatible, cross linked polymers known as hydrogels, which have been used as biocompatible materials and in controlled release devices, especially in controlled delivery of drugs, peptides and proteins, development of novel biomaterials, biomedical transport phenomena, and biointerfacial problems. Our polymer research has examined fundamental aspects of the thermodynamics of polymer networks in contact with penetrants, the conformational changes of networks under load or in the presence of a diluent, the anomalous transport of penetrants in glassy polymers, and the kinetics of fast UV-polymerization reactions. In the field of controlled release, his group has provided the fundamental basis for a rational development of such systems. In addition, his work has led to a series of novel controlled release systems known as swelling controlled release systems, a series of pH-sensitive devices for drug delivery and a wide range of bio- and mucoadhesive systems. Other biomedical work of his group had dealt with understanding of transport of biological compounds in tissues, analysis of polymer/tissue interactions, and understanding of the behavior of biomembranes.

Awards

Excellence in Surface Science Award, Surface in Biomaterials Foundation  2011; Distinguished Achievement Award, Biomedical Engineering Society, 2010; Inaugural Fellow, Controlled Release Society, 2010; Acta Biomaterialia Gold Medal, 2010; William Hall Award, SFB, 2010; Southeastern Universities Research Association Distinguished Scientist Award, 2010; Maurice Marie Janot Award, Pharmaceutical Sciences, 2010; Maurice Marie Janot Award, Pharmaceutical Sciences, 2009; Alan S Michaels Distinguished Lectureship in Medical & Biological Engineering, MIT, 2009; Elected to the Institute of Medicine of the National Academies, 2008;  Premio Romulo Garza, Best Research published in 2008, Mexico, 2008; Founders Award, AIChE, 2008; One Hundred Chemical Engineers of the Modern Era, AIChE, 2008; Associate Editor of the AIChE Journal, 2008; Board of the Biomedical Engineering Society, 2008; President, International Union of Societies of Biomaterials Science and Engineering, 2008; Fellow, ASEE, 2008; Inaugural fellow, Materials Research Society, 2008; HighlyCited® ISI Researcher, 2008 ;Pierre Galletti Award, AIMBE, 2008; Institute Lecturer, AIChE, 2007; Career Research Excellence Award, University of Texas, 2007; Most Outstanding ChE Faculty Member, University of Texas, 2007; Jay Bailey Award, Biological Engineering Society,AIChE, 2006; William H. Walker Award, AIChE, 2006;  Best Paper Award, European Controlled Release Meeting, 2006; Dow Chemical Engineering and Lectureship Award, ASEE, 2006; Elected to the National Academy of Engineering, 2006; Elected to the Academy of Medicine, Engineering and Science of Texas, 2006; Chair of College of Fellows, AIMBE, 2006; Consulting Editor, Pharmaceutical Research, 2005; Inaugural Fellow, BMES, 2005; Best Paper Award, International Meeting of the Microencapsulation Society, 2005; Distinguished Scientist Award, Houston Society of Engineering in Medicine and Biology, 2005; Founders Award of the Society for Biomaterials, 2005; Whitaker Graduate Student Award, Society for Biomaterials, 2005;  Elected Member of the French Academy of Pharmacy (Académie Nationale de Pharmacie), 2005; Research Excellence Award for Best Research Paper, Univ Texas, 2004; Materials Research Society Graduate Research Award, 2003; Capsugel Award for Best Graduate Student Research in Controlled Drug Delivery, 2003; Nagai Foundation Award for Research, 2003; Outstanding Chemical Engineer Award, School of Chemical Engineering, Purdue University, 2002; Distinguished Service Award, Department of Biomedical Engineering, Purdue Universit, 2002; President of the Society for Biomaterials, 2003.; Dale Wurster Award in Pharmaceutics, AAPS, 2002; Newsmaker of the Year, ACS, 2002; Eurand Award for Life Achievements in Oral Drug Delivery, CRS, 2002; Sigma Xi University-wide Research Award, Purdue University, 2002; Chorafas Award, Best Dissertation of the University, 2002; General Electric, Senior Research Award, ASEE, 2000; Herbert McCoy Award, Highest Research Achievement, Purdue University, 2000; Heller Award, Best Research, CRS, 2000; APV Award, Best Ph.D. Thesis, APV, 2000; Fellow, AAAS, 2000; Director of the AIChE, 2000; Research Achievement Award in Pharmaceutical Technology, AAPS, 1999; Editor, Advances in Chemical Engineering, 1999- ; Fellow, APS, 1998; Whitaker Best Paper Award, ISAO, 1997; Fellow, AIChE, 1997; Best Doctoral Dissertation Award, Purdue University, 1996; Whitaker Best Paper Award, IEEE, 1996; APV Medal, 1995; Best Paper Award, Annual Meeting AIChE, 1994; Award and Honorary Membership, Italian Society of Medicine and Natural Sciences, 1994; Food, Pharmaceutical and Bioengineering Award, AIChE, 1994; Fellow, Society for Biomaterials, 1994; Potter Award, Best Engineering Teacher, Purdue University, 1994, 1985, 1978; Shreve Prize, Best Chemical Engineering Teacher, Purdue University, 1994, 1992, 1985, 1982, 1980, 1978; Unilever Award, Best Polymer Doctoral Thesis, ACS, 1993; George Westinghouse Award, ASEE, 1992; Clemson Award for Basic Research in Biomaterials, Society for Biomaterials, 1992; Founding Fellow, AIMBE, 1992; Founders Award for Outstanding Research, CRS, 1991; Victor LaMer Award, Best Colloids Doctoral Thesis, ACS, 1991; Polymer Science Pioneer by the Journal Polymer News, 1991; Fellow, AAPS, 1990; Curtis McGraw Award for Outstanding Research, ASEE, 1988; President of the Controlled Release Society, 1987-88; Materials Engineering and Sciences Award, AIChE, 1984; Zyma Foundation Award for the Advancement of Medical and Biological Sciences, 1982; AIChE National Best Counselor Award, 1982; Editor, Biomaterials, 1982-2001; Western Electric Fund Award, ASEE, 1980.

Selected Publications

  • K.M. Wood, G.M. Stone and NA Peppas, “The Effect of Complexation Hydrogels on Insulin Transport in Intestinal Epithelial Cell Models”, Acta Biomaterialia, 6, 48-56 (2010).
  • D.A. Carr and N.A. Peppas, “Assessment of Poly(Methacrylic Acid-co-N-Vinyl Pyrrolidone) as a Carrier for the Oral Delivery of Therapeutic Proteins Using Caco-2 and HT29-MTX Cell Lines”, J Biomed. Mater Res, Part A, 92A, 504-512 (2010).
  • O.Z. Fisher, A. Khademhosseini and N.A. Peppas, “Drug Delivery: Nanoscale Devices” in K. H. J Buschow, R. W. Cahn, M. C. Flemings, B. Ilschner, E. J. Kramer, S. Mahajan and P. Veyssiere, eds, Encyclopedia of Materials: Science and Technology, Elsevier, Oxford, 1-9, 2010.
  • C.L. Bayer, I.J. Trenchard and N.A.Peppas, “Analyzing Polyaniline-poly(2-acrylamidomethylpropane sulfonic acid) Biocompatibility with 3T3 Fibroblasts”, J. Biomater. Sci., Polym. Ed, 21, 623-634 (2010).
  • O.Z. Fisher, A. Khademhosseini, R. Langer and N. A. Peppas, “Bioinspired Materials for Controlling Stem Cell Fate”, Acc. Chem. Res., 43, 419-428 (2010).
  • T. Betancourt, J. Prado, K. Soo and N.A. Peppas, “Characterization of pH-Responsive Hydrogels of Poly(itaconic acid)-g-Poly(ethylene glycol) Prepared by UV-Initiated Free Radical Polymerization as Biomaterials for Oral Delivery of Biological Compounds”, J. Biomed. Mater. Res., 93A, 175-188 (2010).
  • J.P. Shofner, M.A. Phillips and N.A. Peppas, “Cellular Evaluation of Synthesized Insulin-Transferrin Bioconjugates for Oral Insulin Delivery Using Intelligent Complexation Hydrogels“, Macromol. Biosci., 10, 299-306 (2010).
  • J.P. Shofner and N.A. Peppas, “Overview of Biodrug Delivery Systems: Disease Fundamentals, Delivery Problems and Strategic Approaches”, in “Biodrug Delivery Systems: Fundamentals, Applications and Clinical Development,” M. Morishita and K. Park, eds, 1-12, Informa Healthcare, New York, NY, 2010.
  • M. Morishita, E. S. Khafagy, J.P. Shofner, and N.A. Peppas, “Oral Delivery Systems”, in “Biodrug Delivery Systems: Fundamentals, Applications and Clinical Development,” M. Morishita and K. Park, eds, 172-186, Informa Healthcare, New York, NY, 2010.
  • C. L. Bayer, A. A. Konuk and N. A. Peppas, “Development of a Protein Sensing Device Utilizing Interactions between Polyaniline and Polymer Acid Dopant”, Biomed. Microdev., 12, 435-442 (2010).
  • S.R. Marek, C.A. Conn and N.A. Peppas, “Cationic Nanogels Based on Diethylaminoethyl Methacrylate”, Polymer, 51, 1237-1243 (2010)
  • M. A. Phillips, M. L. Gran and N.A. Peppas, “Targeted Nanodelivery of Drugs and Diagnostics”, NanoToday, 5, 143-159 (2010).
  • W.B. Liechty, D. R. Kryscio, B. V. Slaughter and N. A. Peppas, “Polymers for Drug Delivery Systems”, Ann. Revs. Chem. Biomol. Eng., 1, 149-173 (2010).
  • I. Y. Sanchez and N. A. Peppas, “Feedback Control Systems Using Environmentally and Enzymatically Sensitive Hydrogels”, in “Biomedical Applications of Hydrogels Handbook”, R. M. Ottenbrite, K. Park, T. Okano and N.A. Peppas, eds, Springer, New York, 45-65, 2010.
  • D.A. Carr, M. Gomez-Burgaz, M. Boudes and N.A. Peppas, “Complexation Hydrogels for the Oral Delivery of Growth Hormone and Salmon Calcitonin”, Ind. Eng. Chem. Res., 49, 11991-11995 (2010).
  • E. P. Herrero, Eva M. Del Valle and N. A. Peppas, “Protein imprinting by means of alginate based polymer microcapsules”, Ind. Eng. Chem. Res., 49, 9811-9814 (2010).
  • S. S. Khurshid, C. E. Schmidt and N. A. Peppas, “Optimization of Molecularly Imprinted Polymers of Serotonin for Biomaterial Applications”, J. Biomat. Sci., Polym. Ed., 22, 343-362 (2011).