Peppas, Nicholas A. Sc.D.

Cockrell Family Regents Chair in Engineering #6, Family Chair for Department Leadership #1
Professor of Chemical Engineering, Biomedical Engineering and Pharmacy
Chairman of the Department of Biomedical EngineeringProfessor Nicholas Peppas in a suit

Office: BME 3.110A Mailing Address:
Phone: 512-471-6644 The University of Texas at Austin
Fax: 512-471-8227 Department of Chemical Engineering
Email: peppas@che.utexas.edu 200 E Dean Keeton St. Stop C0400
UT Mail: C0400 Austin, TX 78712-1589

Research Areas: Advanced Materials,Polymers & Nanotechnology, Cellular and Biomolecular Engineering and Computational Biomedical Engineering  and Biotechnology

Research Group Website                         

Research Presentation for Prospective Graduate Students

Educational Qualifications

Sc. D., Massachusetts Institute of Technology  (1973)
Dipl. Eng., National Technical University of Athens, Greece  (1971)
Doc. Hon. Causa, University of Ghent, Belgium (1999)
Pharm. D. Hon. Causa, University of Parma, Italy (1999)
Doc. Hon. Causa, University of Athens, Greece (2000)
Doc. Hon. Causa, University of Ljubljana, Slovenia (2012)
Hon., Prof., Sichuan University, China (2012)

Courses Taught

ChE 322 (U): “Chemical Engineering Thermodynamics”
ChE 355 (U): “Introduction to Polymer Science”
ChE 372 (U): “Kinetics and Reaction Engineering”
ChE 379/384 (U/G): “Polymerization Kinetics and Reaction Engineering
ChE 384 (G): “Advances in Biomedical Engineering”
ChE 387M (G): “Mass Transfer”
BME 380J.2 (G): “Quantitative Physiology”
BME 385J (G): “Fields, Forces and Flows in Cellular and Physiological Systems”
BME 385J.4 (G): “Advances in Biomaterials Science and Engineering”
BME 385J (G) and ChE 384 (G): “Bionanotechnology”

Focus

Biomaterials; Molecular modeling of protein structures in contact with biomaterials and tissues; Controlled drug delivery; Modeling of biomedical devices; Biomedical engineering; Bionanotechnology; Molecular recognition processes; Polymer physics; Polymerization reaction engineering; Diffusion in polymers.

Research

Our research contributions have been in several areas of biomaterials, biomolecular engineering, drug delivery, mathematics and simulations of biological and drug/tissue processes, engineering design of novel biological active entities, polymers and biomedical engineering. The multidisciplinary approach of his research in biomolecular engineering blends modern molecular and cellular biology with engineering to generate next-generation systems and devices, including bioMEMS with enhanced applicability, reliability, functionality, and longevity. The fundamental studies of his group have provided valuable results on biomaterials design and development, drug delivery systems and advanced, intelligent, feedback controlled biological systems.

Our group is known for our work on the preparation, characterization and evaluation of the behavior of compatible, crosslinked polymers (hydrogels), which have been used as biocompatible materials and in controlled release devices, especially in controlled delivery of drugs, peptides and proteins, development of novel biomaterials, biomedical transport phenomena, and biointerfacial problems. Our group has provided the fundamental basis for a rational development of intelligent systems. In addition, our work has led to a series of novel environmentally responsive controlled release systems, swelling protein delivery systems, a series of pH-sensitive devices for peptide delivery and a wide range of bio- and mucoadhesive systems. Other biomedical work of our group had dealt with understanding of transport of biological compounds in tissues, analysis of polymer/tissue interactions, and understanding of the behavior of biomembranes. Our polymer research has examined fundamental aspects of the thermodynamics of polymer networks in contact with penetrants, the conformational changes of networks under load or in the presence of a diluent, the anomalous transport of penetrants in glassy polymers, and the kinetics of fast UV-polymerization reactions.

Awards

Giulio Natta Medal, Polytechnic School of Milan, Italy, 2014; Applied Polymer Science Award, American Chemical Society, 2014; Elected to the Academy of Athens, 2014; Nanoscale Science and Engineering Award, AIChE, 2014; Distinguished Scientist Award, International Journal of Nanomedicine, 2013; Benjamin Garver Lamme Excellence in Engineering Education Award, ASEE, 2013; Founders Award, National Academy of Engineering, 2012; Honorary Doctorate, University of Ljubljana, Slovenia, 2012; Elected Honorary Professor, Sichuan University, 2012;   Hocott Distinguished Engineering Research Award, University of Texas at Austin, 2012; Elected to the Royal Academy of Spain (Academia Real), 2012; Nature and BioNIUM Distinguished Researcher and Educator Award, Nature Conferences, 2012; Fellow, American Chemical Society, 2011; Excellence in Surface Science Award, Surface in Biomaterials Foundation  2011; Distinguished Achievement Award, Biomedical Engineering Society, 2010; Inaugural Fellow, Controlled Release Society, 2010; Acta Biomaterialia Gold Medal, 2010; William Hall Award, SFB, 2010; Southeastern Universities Research Association Distinguished Scientist Award, 2010; Maurice Marie Janot Award, Pharmaceutical Sciences, 2010; Maurice Marie Janot Award, Pharmaceutical Sciences, 2009; Alan S Michaels Distinguished Lectureship in Medical & Biological Engineering, MIT, 2009; Elected to the Institute of Medicine of the National Academies, 2008;  Premio Romulo Garza, Best Research published in 2008, Mexico, 2008; Founders Award, AIChE, 2008; One Hundred Chemical Engineers of the Modern Era, AIChE, 2008; Associate Editor of the AIChE Journal, 2008; Board of the Biomedical Engineering Society, 2008; President, International Union of Societies of Biomaterials Science and Engineering, 2008; Fellow, ASEE, 2008; Inaugural fellow, Materials Research Society, 2008; HighlyCited® ISI Researcher, 2008 ;Pierre Galletti Award, AIMBE, 2008; Institute Lecturer, AIChE, 2007; Career Research Excellence Award, University of Texas, 2007; Most Outstanding ChE Faculty Member, University of Texas, 2007; Jay Bailey Award, Biological Engineering Society,AIChE, 2006; William H. Walker Award, AIChE, 2006;  Best Paper Award, European Controlled Release Meeting, 2006; Dow Chemical Engineering and Lectureship Award, ASEE, 2006; Elected to the National Academy of Engineering, 2006; Elected to the Academy of Medicine, Engineering and Science of Texas, 2006; Chair of College of Fellows, AIMBE, 2006; Consulting Editor, Pharmaceutical Research, 2005; Inaugural Fellow, BMES, 2005; Best Paper Award, International Meeting of the Microencapsulation Society, 2005; Distinguished Scientist Award, Houston Society of Engineering in Medicine and Biology, 2005; Founders Award of the Society for Biomaterials, 2005; Whitaker Graduate Student Award, Society for Biomaterials, 2005;  Elected Member of the French Academy of Pharmacy (Académie Nationale de Pharmacie), 2005; Research Excellence Award for Best Research Paper, Univ Texas, 2004; Materials Research Society Graduate Research Award, 2003; Capsugel Award for Best Graduate Student Research in Controlled Drug Delivery, 2003; Nagai Foundation Award for Research, 2003; Outstanding Chemical Engineer Award, School of Chemical Engineering, Purdue University, 2002; Distinguished Service Award, Department of Biomedical Engineering, Purdue Universit, 2002; President of the Society for Biomaterials, 2003.; Dale Wurster Award in Pharmaceutics, AAPS, 2002; Newsmaker of the Year, ACS, 2002; Eurand Award for Life Achievements in Oral Drug Delivery, CRS, 2002; Sigma Xi University-wide Research Award, Purdue University, 2002; Chorafas Award, Best Dissertation of the University, 2002; General Electric, Senior Research Award, ASEE, 2000; Herbert McCoy Award, Highest Research Achievement, Purdue University, 2000; Heller Award, Best Research, CRS, 2000; APV Award, Best Ph.D. Thesis, APV, 2000; Fellow, AAAS, 2000; Director of the AIChE, 2000; Research Achievement Award in Pharmaceutical Technology, AAPS, 1999; Editor, Advances in Chemical Engineering, 1999- ; Fellow, APS, 1998; Whitaker Best Paper Award, ISAO, 1997; Fellow, AIChE, 1997; Best Doctoral Dissertation Award, Purdue University, 1996; Whitaker Best Paper Award, IEEE, 1996; APV Medal, 1995; Best Paper Award, Annual Meeting AIChE, 1994; Award and Honorary Membership, Italian Society of Medicine and Natural Sciences, 1994; Food, Pharmaceutical and Bioengineering Award, AIChE, 1994; Fellow, Society for Biomaterials, 1994; Potter Award, Best Engineering Teacher, Purdue University, 1994, 1985, 1978; Shreve Prize, Best Chemical Engineering Teacher, Purdue University, 1994, 1992, 1985, 1982, 1980, 1978; Unilever Award, Best Polymer Doctoral Thesis, ACS, 1993; George Westinghouse Award, ASEE, 1992; Clemson Award for Basic Research in Biomaterials, Society for Biomaterials, 1992; Founding Fellow, AIMBE, 1992; Founders Award for Outstanding Research, CRS, 1991; Victor LaMer Award, Best Colloids Doctoral Thesis, ACS, 1991; Polymer Science Pioneer by the Journal Polymer News, 1991; Fellow, AAPS, 1990; Curtis McGraw Award for Outstanding Research, ASEE, 1988; President of the Controlled Release Society, 1987-88; Materials Engineering and Sciences Award, AIChE, 1984; Zyma Foundation Award for the Advancement of Medical and Biological Sciences, 1982; AIChE National Best Counselor Award, 1982; Editor, Biomaterials, 1982-2001; Western Electric Fund Award, ASEE, 1980.

Selected Publications

  • A. Khademhosseini, and  N. A. Peppas, Micro- and Nanoengineering of Biomaterials for Healthcare Applications, Adv. Healthcare Mater., 2, 10-12 (2013)
  • J. M. Knipe, J. Peters and N. A. Peppas, “Theranostic agents for gene delivery and spatiotemporal tracking”, NanoToday, 8, 21-38 (2013).
  • C.A. Schoener, H.N. Hutson and N.A. Peppas, Amphiphilic Interpenetrating Polymer Networks for the Oral Delivery of Chemotherapeutics, AIChE J. 59, 1472-1478 (2013).
  • S. Marek and N. A. Peppas, “Insulin Release Dynamics from Poly(diethylaminoethyl methacrylate) Hydrogel Systems”, AIChE J., 59, 3578-3585 (2013).
  • N. A. Peppas, “Historical Perspectives on Advanced Drug Delivery: How engineering design and mathematical modeling helped the field mature“, Adv. Drug Deliv. Reviews, 65, 5-9 (2013).
  • A. S. Puranik, E. R. Dawson and N.A. Peppas, “Recent Advances in Drug Eluting Stents”, Intern. J Pharmac., 441, 665-679 (2013).
  • S. Steichen, M. E. Caldorera-Moore and N. A. Peppas, “Nanoparticles and Targeting Moieties for the Delivery of Cancer Therapeutics”, Europ. J. Pharm. Sci., 48, 416-427 (2013).
  • D. Forbes, M. Creixell, H Frizzell and N.A. Peppas, Polycationic nanoparticles synthesized using ARGET ATRP for drug delivery, Europ. J. Pharm. Biopharm., 84, 472-478 (2013).
  • C.A. Schoener, B. Carillo-Conde, H.N. Hutson and N.A. Peppas, An Inulin and Doxorubicin Conjugate for Improving Cancer Therapy, J. Drug Deliv. Sci. Technol. 23, 111-118 (2013).
  • C.A. Schoener, H.N. Hutson, N.A. Peppas, pH-Responsive Hydrogels with Dispersed Hydrophobic Nanoparticles for the Oral Delivery of Chemotherapeutics, J. Biomed. Mater. Res. A 101, 2229-2236 (2013).
  • C.A. Schoener  and N.A. Peppas, pH-Responsive hydrogels containing PMMA nanoparticles: an analysis of controlled release of a chemotherapeutic conjugate and transport properties, J. Biomat. Sci. Polym. Ed. 24, 1027-1040 (2013).
  • E Losi, N Peppas, G Colombo, R Bettini, F Sonvico and P Colombo, Investigation of Swelling Behavior of Dome Matrix® Drug Delivery Module by X-Ray Tomography, J. Drug. Deliv. Sci. Technol. 23, 165-170 (2013).
  • W.B. Liechty, R.L. Scheuerle and N.A. Peppas, “Tunable, responsive nanogels containing tert-butyl methacrylate and 2-(tert-butylamino)ethyl methacrylate“, Polymer 54, 3784-3795 (2013).
  • D. Forbes and N.A. Peppas, “Differences in molecular structure in cross-linked polycationic nanoparticles synthesized using ARGET ATRP or UV-initiated polymerization”, Polymer 54, 4486-4492 (2013).
  • N. Annabi, A. Tamayol, J.A. Uquillas, M. Akbari, L. Bertassoni, C. Cha, G. Camci-Unal, M. Dokmeci, N.A. Peppas and A. Khademhosseini, Emerging Frontiers in Rational Design and Application of Hydrogels in Regenerative Medicine, Adv. Materials, 26, 85-124 (2014).
  • A. K. Gaharwar, N. A. Peppas, A Khademhosseini, Nanocomposite Hydrogels for Biomedical Applications, Biotechnology & Bioengineering, 111, 441-453 (2014)
  • L. A. Sharpe, A.  Daily, S. Horava and N. A. Peppas, Therapeutic applications of hydrogels in oral drug delivery. Exp. Opinion on Drug Delivery, 11, 901-915 (2014).
  • D. C. Forbes and N. A. Peppas, Polycationic Nanoparticles for siRNA Delivery: Comparing ARGET ATRP and UV-initiated Formulations, ACS Nano, 8, 2908-2917 (2014).
  • M. C. Koetting and N. A. Peppas, pH-Responsive poly(itaconic acid-co-N-vinylpyrrolidone) hydrogels with reduced ionic strength loading solutions offer improved oral delivery potential for high isoelectric point-exhibiting therapeutic proteins, Intern J Pharmac, 471, 83-91 (2014).
  • H. Culver, A. Daily, A. Khademhosseini and  N.A. Peppas, Intelligent recognitive systems in nanomedicine, Current Opinions in Chemical Engineering, 4, 105-113 (2014).
  • M Durán-Lobato, B Carrillo-Conde, Y Khairandish, NA Peppas, Surface-modified P(HEMA-co-MAA) Nanogel Carriers for Oral Vaccine Delivery: Design, Characterization, and Targeting Evaluation, Biomacromolecules, 15, 2725-2743 (2014).
  • D. C. Forbes and N. A. Peppas, Polymeric Nanocarriers for  siRNA Delivery to Murine Macrophages, Macromol Biosci., published on line, DOI: 10.1002/mabi.201400027.
  • J.M. Knipe, F. Chen, N.A. Peppas, Multi-responsive polyanionic microgels with inverse pH responsive behavior by encapsulation of polycationic nano gels, J Appl Polym Sci, published on line DOI: 10.1002/app.40098.
  • NA Peppas, B Narasimhan, Mathematical models in drug delivery: How modeling has shaped the way we design new drug delivery systems,  J. Controlled Release, published on line DOI: 10.1016/j.jconrel.2014.06.041
  • A Singh, NA Peppas, Hydrogels as scaffolds for immunomodulation, Adv. Mater., published on line DOI: 10.1002/adma.201402105.