Maynard, Jennifer Ph.D.
Laurence E. McMakin, Jr. Centennial Faculty Fellow
|Office:||CPE 5.466||Mailing Address:|
|Phone:||(512) 471-9188||The University of Texas at Austin|
|Fax:||(512) 471-7060||Department of Chemical Engineering|
||200 E Dean Keeton St. Stop C0400|
|UT Mail:||C0400||Austin, TX 78712-1589|
Research Areas: Biotechnology
Ph.D., Chemical Engineering, University of Texas at Austin (2002)
B.A., Human Biology, Stanford University (1996)
NIH Postdoctoral Fellow, Microbiology & Immunology, Stanford University (2002-2004)
CHE 317 Material and Energy Balances
CHE 363 Mass Transfer and Separations
CHE 379/384 Quantitative Analysis of Molecular and Cellular Biology
Biotechnology, vaccine development, protein therapeutics, applied immunology and applied microbiology.
Building on decades of basic research in the biological sciences, fundamental principles underlying the function of complex biological systems are being elucidated in laboratories throughout the world. Concurrently, this understanding renders biology amenable to engineering approaches – how can scientists control, predict and thus design novel biological systems?
We use genetic engineering and biochemical techniques to address issues in immune system function and dis-function, with a view to correcting or augmenting this function. This work involves design of protein molecules, production in recombinant expression systems, biophysical and biochemical analysis and, ultimately, structural analysis to visualize the molecular basis of activity.
Overall research goals:
- Control of cellular immunity through manipulation of T cell receptor interactions
- Define neutralizing epitopes in Bordetella pertussis and use this information to engineer more effective sub-unit vaccines
- Reverse engineer bacterial virulence factors for biotechnological applications
- Apply protein engineering to issues in structural biology
Awards & Honors
Most Outstanding Professor in Chemical Engineering, Student Engineering Council (2010)
Packard Fellowship, David and Lucile Packard Foundation (2005)
Dreyfus New Faculty Award (2003)
National Research Service Award, NIH (2002)
- Sutherland JN, Chang C, AaseA and MaynardJA. Potent neutralization of pertussis toxin through altered intracellular trafficking, submitted.
- Roy BR and Maynard JA. Flanking residues are central to stimulation of DO11.10 T cell hybridoma by ovalbumin 323-339 peptide, submitted.
- Sutherland, JN and Maynard, JA. Serum antibodies binding a potently neutralizing epitope on pertussis toxin. Clinical Vaccine Immunology, in press (2011).
- PaiJC, DruryJE, Lieberman R and Maynard, JA.Peptide-specific antibody scFv chaperones for membrane protein co-crystallization. Protein Engineering Design and Selection, 24(5): 419-28 (2011).
- Ramalingam, K.I., Tomshine, J., Maynard, J.A. and Kaznessis, Y. “Forward engineering of synthetic biological AND-gates.” J Biochemical Engineering, 47: 38-47 (2009).
- Sutherland, JN and Maynard, JA. Characterization of a key neutralizing epitope on pertussis toxin recognized by the monoclonal antibody 1B7, Biochemistry, 48: 11982-11993 (2009).
- Maynard, JA, Lindquist, N, Sutherland, JN, Warrington, AE, Rodriguez, M, and Oh, SH. “Surface plasmon resonance for high-throughput ligand screening of membrane-bound proteins.” Biotechnology J, 4(11): 1542-1558 (2009).
- Leysath, CE, Monzingo, AF, Maynard, JA, Barnett, J, Georgiou, G, Iverson, BL, and Robertus, JD. “Crystal Structure of the Engineered Neutralizing Antibody M18 Complexed to the Anthrax Protective Antigen.” J Molecular Biology 387 (3): 680-693 (2009).
- Pai, J.C., Sutherland, J. and Maynard, J.A. “Progress towards recombinant anti-infective antibodies.” Recent patents in anti-infective drug discovery. 4(1):1-17 (2009).
- Sivasubramanian, A., Maynard, J.A., and Gray, J.J. “Modeling the structure of mAb 14B7 bound to the anthrax protective antigen.” Proteins: Structure, Function, Bioinformatics, 70(1): 218-230 (2008).
- Feng, D., Bond, C., Ely, L., Maynard, J. and Garcia, K.C. “Structural evidence of a germline-encoded T cell receptor-major histocompatibility complex interaction ‘codon.’” Nature Immunology, 8(9): 975-983 (2007).
- Maynard, J, Myhre, R., and Roy, B. “Microarrays in infection and immunity.” Current Opinion in Chemical Biology. 11(3): 306-315 (2007).
- Maynard, J., Adams, E. J., Krogsgaard, M., Petersson, K., Liu, C. and Garcia K. C. “High-level bacterial secretion of ab T Cell Receptors.” Journal of Immunological Methods 306: 51-67 (2005).
- Maynard, J., Petersson, K. P., Wilson, D. H., Adams, E. J., Blondelle, S. J., Boulanger, M. J., Wilson, D. B., and Garcia, K. C. “Structure of an autoimmune T cell receptor complexed with class II peptide-MHC: insights into MHC bias and antigen specificity.” Immunity, 22: 81-92 (2005).