Georgiou, George Ph.D.

Professor, Cockrell Family Regent’s Chair in Engineering #9

photo of George Georgiou
Office: CPE 4.410 Mailing Address:
Phone: (512) 471-6975 The University of Texas at Austin
Fax: Department of Chemical Engineering
Email: gg@che.utexas.edu 200 E Dean Keeton St. Stop C0400
UT Mail: C0400 Austin, TX 78712-1589

Research Areas: Biotechnology

Research Website

Research Presentation for Prospective Graduate Students

Educational Qualifications

Ph.D., Chemical Engineering, Cornell University (1987)
M.S., Chemical Engineering, Cornell University (1983)
B.Sc., Chemical Engineering, University of Manchester Institute of Science and Technology (UMIST), England (1981)

Courses Taught

CHE 339          “Introduction to Biochemical Engineering,” undergraduate (25 semesters)
CHE 317          “Chemical Engineering Analysis and Calculations,” undergraduate (two semesters)
CHE 322          “Thermodynamics,” undergraduate (four semesters)
CHE 264          “Chemical Engineering Process Laboratory,” undergraduate, (two semesters)
CHE 395F        “Advanced Biochemical Engineering,” graduate (three semesters)
CHE 384N       “Fermentation Technology,” graduate (two semesters)
CHE 384K       “Biomolecular Recognition” graduate (four semesters)

Focus

Biotechnology

Research

Our group employs molecular biology and genetic approaches for the design and production of proteins with improved function and for the engineering of cellular physiology. Current research projects include:

  1. Development of new technologies to aid protein engineering and drug discovery
  2. Engineering of therapeutic and diagnostic antibodies
  3. Engineering of novel enzymes
  4. The mechanism of oxidative protein folding in bacteria
  5. Protein secretion pathways in bacteria
  6. Regulation of RNA turnover
  7. Biologically templated nanomaterials

Awards & Honors

Named as one of “100 Eminent Chemical Engineers of the Modern Era,” American Institute of Chemical Engineering (AIChE 2008)
Jay Bailey Award, Society of Biological Engineers (2007)
AMGEN Award in Biochemical Engineering (2007)
Food, Pharmaceutical and Bioengineering Award, American Institute of Chemical
Engineering (AIChE 2005)
National Academy of Engineering (NAE 2005)
Fellow, American Academy of Microbiology (2004)
Fellow, American Association for the Advancement of Science (2004)
Professional Progress Award for Outstanding Progress in Chemical
Engineering, American Institute of Chemical Engineering (AIChE 2003)
Marvin J. Johnson Award in Microbial and Biochemical Technology,
American Chemical Society (ACS 2003)
Fellow, American Institute for Medical and Biological Engineering (AIMBE 1996)
E. Bergman Award, US-Israel Science Foundation (1995)
Presidential Young Investigator Award, National Science Foundation (1987)

Selected Publications

  • Feeney, M.A., Veeravalli, K., Boyd, D., Gon, S., Faulkner, M.J., Georgiou, G. & Beckwith. J., “Rewiring Major Electron Flow Pathways in E.coli by a Single Amino Acid Change in Lipoamide Dehydrogenase”  Proc. Natl. Acad. Sci. USA (accepted).
  • Cantor J. R., Yoo, T.-H., Dixit, A., Iverson, B.L., Forsthuber, T.G. & G. Georgiou, “Therapeutic Enzyme De-immunization by Combinatorial T-Cell Epitope Removal using Neutral Drift, Proc. Natl. Acad. Sci. USA108:1272-77 (2011).
  • Veeravalli, K.,  Boyd, D.,  Iverson, B.L., Beckwith, J. & G. Georgiou, “Laboratory Evolution of Glutathione  Biosynthesis Reveals Natural Compensatory Pathways,” Nature Chem. Biol. 7:101-105 (2011).
  • Stone, E.M., Chantranupong, L., & G. Georgiou, “The Second Shell Metal Ligands of Human Arginase Affect Coordination of Nucleophile and Substrate” Biochemistry 49:10582-8 (2010) PMID: 21053939
  • Reddy, R.T., Ge, X.,  et al. & G. Georgiou, “ Isolation of Monoclonal Antibodies Without Screening by Mining the Variable Gene Repertoire of Plasma Cells,”  Nature Biotechnol.  28:965-9 (2010).
  • Stone, M.S, Chantranupong, L, Glazer S.E, Cherukuri, P., Breece, R.M., Tierney D.L., Curley S.A. and G. Georgiou, “Replacing Mn+2 with Co+2 in Human Arginase I Enhances Cytotoxicity Towards L-Arginine Auxotrophic Cancer Cell Lines” ACS Chemical Biology 5:333-42 (2010) PMID: 20050660
  • Jung, S.T., Reddy, S., Kang, T.H, Borrok, J.M., Sandlie, I., Tucker, P.W. and G.  Georgiou, “Aglycosylated IgG Variants Expressed in E. coli that Selectively Bind FcgRI Potentiate Tumor Cell Killing by Monocyte-Derived Dendritic Cells,” Proc Natl Acad Sci USA 107:604-9 (2010) PMID: 20080725