| My current project
is titled “Investigation of
the Solid State Interactions Occurring between
Polymers and Macromolecules during Hot-Melt Extrusion.”
Preliminary findings have demonstrated that chemical
interactions between carrier polymers and ionic
macromolecules occur in both the solid state and
in aqueous media. The resulting solid extrudates
release drug in vitro, independent of pH, and
the drug release profiles follow a zero-order
mechanism. The properties of extruded materials
and physical mixtures are studied by using thermal
analysis, such as DSC and/or modulated DSC, powder
X-ray diffraction and FT-IR. Solid-state NMR (13C
CP/MAS NMR) is used to investigate the interactions
between polymers and drug or other ingredients,
since a chemical shift is affected by solid state
interaction.
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