Laboratory Research

Our Laboratory of Biomaterials, Drug Delivery, Bionanotechnology and Molecular Recognition has been the leading group and pacesetter in the field of drug delivery and controlled release, a field that has been developed into a mature area of scholarly and applied research. In addition we have had extensive contributions in biomaterials and bionanotechnology, and have contributed seminal work in the field of feedback controlled biomedical devices. The multidisciplinary approach of this research in bionanotechnology and biomolecular engineering blends modern molecular and cellular biology with engineering to generate next-generation systems and devices, including bioMEMS with enhanced applicability, reliability, functionality, and longevity. Our contributions have been translated into more than twenty medical products with multibillion dollar markets.

Fundamentals of Biomedical and Pharmaceutical Transport Systems: The fundamentals and rational design of drug delivery systems and biomaterials have been set by our group over the past 35 years. In its very early days, drug delivery was an empirical field where the selection of components for successful formulations was based on a heuristic approach. Peppas and collaborators were the first to set the theories and equations that led to the design of a wide range of new systems. For example, using biomedical engineering principles and new biomedical transport theories, they developed the equations that describe Fickian and non-Fickian diffusion in controlled release devices. The “Peppas equation” has become the standard method of analysis of any pharmaceutical device. Using the modeling similarities of phase erosion and state erosion, they developed a unified models for all drug delivery systems. Similarly, they developed the theoretical framework for the analysis of transport through crosslinked biomaterials (the Peppas-Reinhart theory), ionic hydrogels (the Brannon-Peppas theory), and gel-tissue interactions via tethers (the Huang-Peppas theory and the Sahlin-Peppas equation). For the impact of these theories and analyses, Dr. Peppas has been recognized as the most cited and highly published author in drug delivery, biomaterials and drug delivery, and intelligent materials ( Web of Science ® 2012). He has also ranked as one of the most cited scientists with 60,008 citations (more than half of them in just the last five years) and an H-index of 120 (link) including nine contributions with more than 1,000 citations each.

Biomedical and Pharmaceutical Devices: Applications of these theories have had significant impact in the development of new biomedical systems and devices. Peppas and his students originated the novel muco- and bioadhesive systems that interact molecularly with the mucus and tissue and have been able to prolong bioavailability of proteins and peptides in the blood. As a result of his work, a number of biomedical polymers and commercial delivery devices have been launched. For example, our group was the first to develop novel toxic-free poly(vinyl alcohol) gels by the freezing-thawing technique in 1975. These gels became very successful articular cartilage replacement systems. In 1978, the group developed the same systems for in situ replacement of vocal cords, a successful medical procedure that remained in practice until the late 1990s and assisted about 45,000 patients.

Intelligent Hydrogels: This laboratory group pioneered (1979) the use of hydrogels in drug delivery applications, including epidermal bioadhesive systems and systems for the release of theophylline, proxyphylline, diltiazem, and oxprenolol. Perhaps the most important development of our labs has been the new technologies of oral delivery systems for insulin and other proteins. These devices release insulin orally, “protecting” the insulin throughout its transport in the stomach, upper small intestine, and, eventually, blood, and bypassing diabetics’ need for several daily injections. Dr. Peppas’ group has shown that these new systems exhibit very high bioavailability. This is the first time that an oral system has been shown to be effective for oral delivery of proteins, especially insulin. In fact, the same technology has been used for the transmucosal (oral, buccal) delivery of calcitonin (for treatment of osteoporosis in postmenopausal women) and interferon-alpha (for cancer therapy), and is presently investigated for interferon-beta release for multiple sclerotic patients. In tests on over 1500 rats and dogs that were given capsules containing microspheres of this new biomaterial carrier, high bioavailability was determined.

Intelligent, Feedback Control-Based Systems: Dr. Peppas was one of the pioneers of intelligent biomaterials, and medical devices. Using intelligent polymers as early as 1980, the Peppas group were the first to use such pH-sensitive and temperature-sensitive systems for modulated release of streptokinase and other fibrinolytic enzymes. In the 1990s and in this century, Dr. Peppas became the main proponent of the use of intelligent systems in the medical field. Physiologically-controlled and disease-responsive, feedback control-based devices require the operation/function of electrical and mechanical parts as a result of on-line measurement of physiological variables of the body, blood or other biological fluids. Peppas utilized the basics of biomedical transport phenomena, control theory, and kinetic behavior to design novel devices and to optimize their behavior in the body or in contact with the body. Adjustment of appropriate components of these devices was based on simple or sophisticated control or other physiological based models. To this end, Dr. Peppas and his group have investigated the biocompatibility of all components of these devices and have provided knowledge of cellular response mechanisms that may be related to changes in immunological status, physical tissue damage. Research in physiologically-responsive devices has sought to show how it is possible to use classical and biomedical engineering principles, mathematics, transport phenomena and control theory to design devices and artificial organs, often based on "intelligent materials," which are responsive to changes in the surrounding environment. Dr. Peppas developed feedback control devices, such as glucose-sensitive microsensors that can respond to abnormal glucose levels by releasing incorporated insulin to the blood at desired rates. Such feedback control systems could be perfected for use in treatment of diabetes. In addition, he developed temperature-sensitive devices that can be used for treatment of malaria by release of antipyretics. A natural consequence of this work was his founding of Mimetic Solutions, a company that commercializes these devices and is in the forefront of intelligent device and bioMEMs development.

1977-1990 1991-2000 2001-2006 2007-2013
Todd W.B Gehr Myung Cheon Lee Franco Barbato* Terry G. Farmer
Yen Bao* Christopher N. Bowman Yanbin Huang Lisa Lao*
Robert Gurny* Dukjoon Kim Petr Bures Irma Sanchez
Ming-Shin Yen Jennifer J. Sahlin Madeline Torres-Lugo Jeff Wilson
Lucy Lucht-Hair Atul R. Khare Hideki Ichikawa* Ruben Morones
Richard W. Korsmeyer Jianchu Wu William Leobandung Omar Fisher
Donald R. Miller Esmaiel Jabbari Aaron Foss Daniel Carr
Christian Bindschaedler Kristi Anseth Alexander Streubel Amber Doiron
G.W. Raymond Davidson III Deepak Hariharan  Bumsang Kim Justin Shofner
Serge Segot-Chicq Mary T. am Ende Sasa Baumgartner* Melissa A. Kanzelberger
Frederic Touchard Cristi L. Bell Ebru Oral Tania Betancourt*
Frederique Pothier-Lallemand J. Eric Dietz Marcos Garcia* Edgar Perez Herrero
Guillaume Conrath Devdatt L. Kurdikar Till Bussemer Carolyn Bayer
Bruno Gander Alessia deAscentis Cristina Donini Steve Marek
Christian Robert Ruggero Bettini Oya Sipahigil-Kerimoğlu Diana Snelling van Blarcom
Tae-Ho Kim* Balaji Narasimhan Mark Byrne Marta Gomez-Burgaz*
Hai-Shung Andy Tsou Surya Mallapragada Jay O. Blanchette Adam Ekenseair
Catherine Dubernet Christopher S. Brazel J. Zachary Hilt Martin L. Gran
M. Lisa Brannon Anthony M. Lowman David B. Henthorn Margaret Phillips-Gran
Ronald S. Harland Robert A. Scott Nikhil Kavimandan David Kryscio
Antonios G. Mikos Kairali Podual Nicole M. Bergmann Coro Echeverria
John Klier Christie M. Hassan-Bures Gianfranco Spizzirri* Cody Schoener
Steven Lustig Robert S. Parker Laura Serra Mar Creixell*
Mara Lovrecich* Jürgen Siepmann Elena Losi Eileen Dawson
Paolo Giunchedi* Mette Ingemann Kristy M. Wood William Liechty
Lauretta Maggi* Jing Zhang J. Brock Thomas Mary Caldorera-Moore*
Alec B. Scranton Jennifer Harting Ward E. Hunter Lauten Brenda Carrillo-Conde*
Olivier Saslawski   Donald E. Owens III  

* Green indicates those in academic positions
* Asterisk indicates former post docs

Celebration of the Founding of AICHE 100 Years Ago with article in the chemical heritage foundation magazine by Nicholas Peppas (Fall 2008) (click here)

PDF Version: Page 1 | Page 2

Photos of Students During NAP Tenure at Univ. of Texas

Profile of a husband and wife team: Nicholas and Lisa (PDF Version)

 

 


Video Presentations Featuring Lab Research


Current News

Two papers published in the Journal of Controlled Release by P. Ritger and N. Peppas (link) and (link) are the most cited original papers in the 30-year history of the journal. A special article has been commissioned for this occasion for publication in JCR.

A paper from the lab, titled "An Inulin and Doxorubicin Conjugate for Improving Cancer Therapy" authored by Cody Schoener (ChE PhD'12, NSF Fellow), Brenda Carrillo-Conde (Post-doctoral fellow), Heather Hutson (BME BS'12, NSF Fellow at Univ. of Wisconsin-Madison) and Nicholas Peppas, won the 2013 best paper award of the Journal of Drug Delivery Science and Technology. The award will be given during the World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology in Lisbon on March 31- April 4 (link).

On November 28, 2013, Professor Peppas was elected a Corresponding Member of the Academy of Athens (link, link in Greek, link in English). He will be inducted to the Academy and present an inaugural lecture in 2014 in the magnificent Academy building with the imposing statues of Socrates and Plato at its entrance.

A symposium in honor of Nicholas Peppas (link) has been organized at the ACS meeting In Dallas, TX by his former PhD student and now distinguished professor at Colorado, Chris Bowman. The list of invited speakers includes some of the leading names in macromolecular and biopolymer science including his former students Chris Bowman, Antonios Mikos, Kristi Anseth, John Klier and Balaji Narasimhan, his colleagues and/or collaborators Tom Truskett, Chris Ellison, Grant Willson and Ali Khademhosseini, and other friends and leading figures in the field such as Krzysztof Matyjasewski, Chad Mirkin, Sharon Glotzer, Matt Tirrell, Curt Frank, Sam Stupp, Joe DeSimone, Jindrich Kopecek and Buddy Ratner.

On March 6, Nicholas Peppas presented the Kammermeyer Lecture in the Department of Chemical and Biochemical Engineering of the University of Iowa (link)

Nicholas Peppas presented the 2014 Skalak Lecture in the Bioengineering Department of the University of California at San Diego on February 10, 2014 (link, link).

Nicholas Peppas presented an invited lecture on Molecular Imprinting and Recognitive Medical Devices at the University of Minho in Braga, Portugal (link).

Nicholas Peppas is featured in C&E News of January 6, 2014 on the occasion of the 2104 ACS Applied Polymer Science Award (link).

Nicholas Peppas is the 2013 recipient of the International Journal of Nanomedicine Distinguished Scientist Award. He presented the award winning lecture on "Advanced Biomaterials and Nanotechnology for Improved Health Care" as an inaugural lecture for the Materials Research Society (MRS) symposium "Advanced Composites and Structures for Tissue Engineering" on Monday, December 2, 2013 in Boston.

Laboratory researcher and Chemical Engineering PhD candidate Jenny Knipe won the first prize from the Society of Women Engineers Technical Poster Competition for her paper on Biodegradable microencapsulated nanogel system for the oral delivery of siRNA in Baltimore, MD, on October 25, 2013 (link).

Nicholas Peppas is the winner of the 2013 Nanoscale Science and Engineering Forum Award for his achievement in nano-science and technology, impact in education, and commitment to professional service. He delivered his lecture on "Intelligent and Recognitive Nanoscale Systems for a New Generation of Therapeutic Applications" (link) at the AIChE meeting on Monday, November 4, 2013 at 4:05 pm (link).

Nicholas Peppas presented the 2013 Hoffman Lecture at the University of Washington Bioengineering Department (link). He spoke on "Hydrogels, Intelligence and Therapeutic Systems: Is there a Future?". The Lecture was established in 2010 in honor of professor Allan Hoffman.

Nicholas Peppas and Teruo Okano presented two plenary lectures at the European Society for Biomaterials meeting in Madrid, Spain on September 8, 2013 (link). Peppas spoke on "Novel Intelligent and Recognitive Carriers for siRNA delivery and theranostics"

Nicholas Peppas gave one of four plenary lectures (link) 19th International Symposium on Microencapsulation in Pamplona, Spain on September 10, 2013. He spoke about "Advanced Responsive and Feedback-controlled nanoparticles for consumer and cosmetic applications".

Dr. Peppas participated and chaired the "Workshop on Key Challenges in the Implementation of Convergence" (link) sponsored by the Board on Life Sciences of the National Academy of Sciences (link). BME graduate students Stephanie Steichen and Lindsey Sharpe participated by invitation as well.

Nicholas Peppas and Kazunori Kataoka were the plenary lecturers in the 5th Asian Arden Conference in Nagoya, Japan (link). Peppas spoke on Novel Intelligent and Recognitive Carriers for siRNA Delivery and Theranostics.

The Peppas Factor: Educating Future Leaders An article about Dr. Peppas' educational contributions and teaching style (link)(pdf).

June 27: Steve R. Lustig (MS 85, PhD '88) of the DuPont company is the winner of the 2013 Industrial Research & Development Award of the American Institute of Chemical Engineers (AIChE). He will receive the award at the annual AIChE meeting in San Francisco in November.

Dr. Peppas talked about "Advances in Intelligent Hydrogels for Recognitive and Protein Delivery Systems" at the Institute of Bioengineering, School of Life Sciences & School of Engineering of the Ecole Polytechnique Federale de Lausanne, Switzerland on July 4, 2013.

Professor Nicholas Peppas has been selected to receive the Distinguished Scientist Award of the International Journal of Nanomedicine, The Award recognizes an established scientist who has made significant contributions to the field of nanomedicine. Peppas will receive this award at the Fall Biomedical Engineering Society meeting in Seattle, WA.

Three laboratory researchers received best papers awards for their work presented in the Biomaterials Day of the Society for Biomaterials in Austin, TX, May 31, 2013. Stephanie Steichen and Michael Koetting received the first and second prizes in the graduate students competition, while Hannah Frizzell received the first prize in the undergraduate students competition.

At the Engineering Commencement of Friday, May 17, 2013, graduating senior Rebekah Scheuerle received the outstanding student and leader award of the Cockrell School of Engineering.

Professor Peppas presented a series of lectures at the Faculty of Pharmacy of the University of Belgrade in Serbia. His day course on Fundamentals and Applications of Controlled Release and Drug Delivery was held on May 23, 2013 from 8:00 to 5:00 pm and was open to members of the pharmaceutical and chemical industry.

Professor Nicholas Peppas was the recipient of the 2013 Benjamin Garver Lamme Excellence in Engineering Education Award of the American Society for Engineering Education (ASEE). The ASEE’s Benjamin Garver Lamme Award is the most prominent education award in the nation and was established in 1927. The award acknowledges excellence in teaching, contributions to research and technical literature, and achievements that advance engineering college administration. It was presented at the ASEE Annual Awards Banquet June 26 in Atlanta, Georgia.

Two publications by Richard Korsmeyer (MS '81, PhD '83) and Don Owens (PhD’ 07) and Nicholas Peppas on "Mechanisms of Solute Release from Porous Hydrophilic Polymers" and "Opsonization, Biodistribution, and Pharmacokinetics of Polymeric Nanoparticles" are the most cited papers in the history of the International Journal of Pharmaceutics (link).

Other news...


Awarding of an honorary doctorate from the University of Ghent to Nicholas Peppas, March 1999 (in Flemish and English)

Awarding of an honorary doctorate by the University of Parma to Nicholas Peppas, October 1999 (in Italian)

Awarding of an honorary doctorate by the National and Capodistrian University of Athens, March 2000 (in Greek)

KXAN Interview about Biomedical research, Austin, 2003

Nicholas Peppas gives the 2007 AIChE Institute Lecture

Tribute of NAP by Natalie Wisniewski, Austin, August 8, 2008

Tribute of NAP by Bob Langer, Austin, August 8, 2008

Tribute of NAP by Mike Sefton, Austin, August 8, 2008

Tribute of NAP by Kinam Park, Austin, August 8, 2008

Tribute of NAP by J Zach Hilt, Austin, August 8, 2008

Lisa Brannon-Peppas speaks about NAP, Austin, August 8, 2008

Nicholas Peppas thanks the participants of the 60th Birthday events, Austin, August 8, 2008

Celebration of Michael Sefton's 60th birthday with talks by Peppas and Sefton, Toronto, March 2009

Alan Michaels Lecture, MIT April 3, 2009

Liliane Bettencourt Seminar at College de France, Paris, March 2010 (in French)

Distinguished lecture, Merrill Symposium

Centennial lecture Purdue, October 2011

Inaugural speech upon induction to the National Royal Academy of Spain, March 2012 - Part 1

Inaugural speech upon induction to the National Royal Academy of Spain, March 2012 - Part 2

Nicholas Peppas welcoming speech at the 2012 World Biomaterials Congress

Nicholas Peppas presides to the induction ceremony of new IUSBSE Fellows at the 9th World Biomaterials Congress - Chengdu 2012

Some scenes from the 9th World Biomaterials Congress Closing Event – Chengdu 2012

NAE Founders Award, September 2012- Part 1

NAE Founders Award, September 2012- Part 2

National Academy of Engineering Founders Award Acceptance Speech, September 30, 2012

ASEE Interview of Nicholas Peppas by Les Benet of UCSF, AAPS meeting, Chicago, Oct 2012

Peppas talk on micro encapsulation in consumer and cosmetic products: Microencapsulation meeting, Pamplona Spain September 11, 2013

The Mission of a Biomedical Engineer, November 20, 2013

 

 

 

Fletcher Stuckey Pratt Chair in Engineering

Nicholas A. Peppas, Sc.D.
Departments of Chemical Engineering and Biomedical Engineering, and Division of Pharmaceutics
 
The University of Texas at Austin
1 University Station C0400
Austin, TX 78712-1062
peppas@che.utexas.edu

 

Recent Laboratory Publications

Click for Citations

1. M Durán-Lobato, B Carrillo-Conde, Y Khairandish, NA Peppas, Surface-modified P(HEMA-co-MAA) Nanogel Carriers for Oral Vaccine Delivery: Design, Characterization, and Targeting Evaluation, Biomacromolecules (under review).

2. M Caldorera-Moore, G Fletcher, K. Maas, NA Peppas, Hybrid Responsive Hydrogel Carriers for Oral Delivery of Hydrophobic, Low Molecular Weight Therapeutics, JAPS (under review).

3. A Singh, NA Peppas, Hydrogels as scaffolds for immunomodulation, Adv. Mater., (under review).

4. NA Peppas, B Narasimhan, Mathematical models in drug delivery: How modeling has shaped the way we design new drug delivery systems, J. Controlled Release, (under review).

5. NA Peppas, Commentary on An Exponential Model for the Analysis of Drug Delivery, J. Controlled Release, (in press).

6. DC Forbes, NA Peppas, Polycationic Nanoparticles for siRNA Delivery: Comparing ARGET ATRP and UV-initiated Formulations, ACS Nano, 8, 2908-2917 (2014) (link).

7. H Culver, A Daily, A Khademhosseini, NA Peppas, Intelligent recognitive systems in nanomedicine, Curr. Opinion Chem. Engin., 4, 105-113 (2014) (link).

8. JM Knipe, F Chen, NA Peppas, Multi-responsive polyanionic microgels with inverse pH responsive behavior by encapsulation of polycationic nano gels, J Appl Polym Sci, published on line, DOI: 10.1002/app.40098 (link).

9. LA Sharpe, A Daily, S Horava and NA Peppas, Therapeutic applications of hydrogels in oral drug delivery. Exp. Opinion on Drug delivery, in press.

10. MC Koetting and NA Peppas, pH-Responsive poly(itaconic acid-co-N-vinylpyrrolidone) hydrogels with reduced ionic strength loading solutions offer improved oral delivery potential for high isoelectric point-exhibiting therapeutic proteins, Intern J Pharmac, (under review).

11. DC Forbes, NA Peppas, Polymeric Nanocarriers for siRNA Delivery to Murine Macrophages, Macromol Biosci., (in press).

12. AK Gaharwar, NA Peppas, A Khademhosseini, Nanocomposite Hydrogels for Biomedical Applications, Biotechnology & Bioengineering, under revision. 111, 441-453 (2014) (link).

13. NA Peppas, ME Caldorera-Moore, and SD Steichen, Historical survey of drug delivery devices, in R Siegel and SP Lyu, eds, Drug-Device Combinations for Chronic Diseases, Wiley, New York, NY, in press.

14. N Annabi, A Tamayol, JA Uquillas, M Akbari, L Bertassoni, C Cha, G Camci-Unal, M Dokmeci, NA Peppas and A Khademhosseini, Emerging Frontiers in Rational Design and Application of Hydrogels in Regenerative Medicine, Adv. Materials, 26, 85-124 (2014) (link).

15. D Forbes; NA Peppas, "Differences in molecular structure in cross-linked polycationic nanoparticles synthesized using ARGET ATRP or UV-initiated polymerization", Polymer 54, 4486-4492 (2013) (link).

16. WB Liechty; RL Scheuerle; NA Peppas, "Tunable, responsive nanogels containing tert-butyl methacrylate and 2-(tert-butylamino)ethyl methacrylate", Polymer 54, 3784-3795 (2013) (link).

17. Schoener C A; Carillo-Conde B; Hutson H N; and Peppas N A, An Inulin and Doxorubicin Conjugate for Improving Cancer Therapy, J. Drug Deliv. Sci. Technol. 23, 111-118 (2013) (link).

18. Schoener C A; Hutson H N; Peppas N A, Amphiphilic Interpenetrating Polymer Networks for the Oral Delivery of Chemotherapeutics, AIChE J. 59, 1472-1478 (2013) (link).

19. J. M. Knipe, J.T. Peters and N. A. Peppas, “Theranostic agents for gene delivery and spatiotemporal tracking", NanoToday, 8, 21-38 (2013) (link).

20. N. A. Peppas, “Historical Perspectives on Advanced Drug Delivery: How engineering design and mathematical modeling helped the field mature“, Adv. Drug Deliv. Rev. 65, 5-9 (2013) (link).

21. A. S. Puranik, E. R. Dawson and N.A. Peppas, “Recent Advances in Drug Eluting Stents”, Intern. J Pharmac. 441, 665-679 (2013) (link).

22. S. Steichen, M. E. Caldorera-Moore and N. A. Peppas, “Nanoparticles and Targeting Moieties for the Delivery of Cancer Therapeutics”, Europ. J. Pharmac. Sci., 48, 416-427 (2013) (link).

23. Khademhosseini A, Peppas N A, Micro- and Nanoengineering of Biomaterials for Healthcare Applications, Adv. Healthcare Mater., 2, 10-12 (2013) (link).

24. Schoener C A; Peppas N A, Oral Delivery of Chemotherapeutic Agents: Background and Potential of Drug Delivery Systems for Colon Delivery, J. Drug Deliv. Sci. Technol. 22, 459-468 (2012) (link).

25. Peppas N A, An introduction to the most cited papers in the history of the ADDR journal, Adv. Drug Deliv Rev. 64 1-3 (2012) (link).

26. Cha C, Liechty W, Khademhosseini A, Peppas N A , Designing Biomaterials to Direct Stem Cell Fate, ACS Nano, 6, 9353-9358 (2012) (link).

27. N A Peppas, E Perez-Herrero, Protein Imprinting by Means of Alginate-Based Polymers, US Patent 20,120,276,386 (2012) (link).

28. D Forbes; M Creixell; H Frizzell; NA Peppas, Polycationic nanoparticles synthesized using ARGET ATRP for drug delivery, Europ. J. Pharm. Biopharm., 84, 472-478 (2013) (link).

29. E Losi, N A Peppas, R A Ketcham, G Colombo, R Bettini, F Sonvico, P Colombo, Investigation of Swelling Behavior of Dome Matrix® Drug Delivery Modules by High Resolution X-Ray Computed Tomography, J. Drug. Deliv. Sci. Technol. 23, 165-170 (2013) (link).

30. M Mouton-Johnston, D C Forbes, Controlled release using an oral drug delivery system designed to improve treatment of conditions such as multiple sclerosis, J Youths in Science, 5 (2) 18-20 (2013) (pdf).

31. Bae H; Puranik AS; Gauvin R; Edalat F; Carrillo-Conde B; Peppas N A; Khademhosseini A, Building Vascular Networks, Sci. Transl. Med., 4, 160ps23 (2012) (link).

32. Schoener C A; Peppas N A, pH-Responsive hydrogels containing PMMA nanoparticles: an analysis of controlled release of a chemotherapeutic conjugate and transport properties, J. Biomat. Sci. Polym. Ed. 24, 1027-1040 (2013) (link).

33. Schoener C A; Hutson H N; Peppas N A, pH-Responsive Hydrogels with Dispersed Hydrophobic Nanoparticles for the Oral Delivery of Chemotherapeutics, J. Biomed. Mater. Res. A 101A, 2229-2236 (2013) (link).

34. Peppas N A, Promoting Convergence in Biomaterials Science and Engineering, Annals Chinese Acad. Engineering (in press).

35. Gran M L; Peppas N A, Metal-Polymer Nanoparticulate Systems for Externally-Controlled Delivery, Adv. Health Care Mater. (under review).

36. Shofner J P; Peppas N A, Oral Delivery of Protein-Transporter Bioconjugates Using Intelligent Complexation Hydrogels, Europ. J. Pharm. Sci. (under review).

37. Phillips M ; Peppas N A, Carbohydrates in Drug Delivery, J. Biomat. Sci., Polym. Ed. (under review).

38. Peppas N A Smart Materials for Drug Delivery: Preface, in Alvarez-Lorenzo C; Concheiro A., Smart Materials for Drug Delivery, RSC Smart Materials Series, London, UK, 2013 (link).

39. S. Marek and N. A. Peppas, “Insulin Release Dynamics from Poly(diethylaminoethyl methacrylate) Hydrogel Systems”, AIChE J., 59, 3578-3585 (2013) (link).

40. D. C. Forbes and N. A. Peppas, “Oral delivery of small RNA and DNA", J. Controlled Release, 162, 438-445 (2012) (link)

41. D. R. Kryscio, M. Q. Fleming and N. A. Peppas, “Protein Conformational Studies for Macromolecularly Imprinted Polymers", Macromol. Biosciences, 12, 1137-1144 (2012) (link).

42. M. Creixell and N. A. Peppas, “Co-delivery of siRNA and Therapeutic Agents Using Nanocarriers to Overcome Multidrug Resistance in Cancer Therapy” , NanoToday, 7, 367–379 (2012) (link).

43. A. K. Ekenseair, R. N. Seidel and N. A. Peppas, “Tuning the Transport Dynamics of Small Penetrant Molecules in Glassy Polymers”, Polymer 53, 4010-4017 (2012) (link).

44. Schoener C A; Hutson H N; Peppas N A, pH-Responsive Hydrogels with Dispersed Hydrophobic Nanoparticles for the Delivery of Hydrophobic Therapeutic Agents, Polym Intern. 61, 874-879 (2012) (link).

Other recent publications...


PubMed Search (for more recent publications including the texts)

Peppas, Nicholas
Peppas, Nicholas A
Peppas, N


National Distinctions of Laboratory Graduates


 

Important videos from the Lab and some of its graduates:

A Mexican TV video about Dr. Irma Yolanda Sanchez (PhD '09 and now professor at the Tecnologico de Monterrey) and her PhD work on insulin delivery. Link: http://www.youtube.com/watch?v=0XE6NCyIanc

Rebekah Scheuerle (ChE BS'13, Gates Cambridge Scholar) is featured in an interview with KXAN (Channel 4, NBC) for being one of the outstanding graduates of the class of 2013 from the University of Texas. Link: http://www.youtube.com/watch?v=8lfm9wh5hag

Rebekah Scheuerle (BS'13, Gates Cambridge Scholar) talks about her work in Prof. Peppas' lab and the drug delivery research she intends to pursue at the University of Cambridge. Link: http://youtu.be/joBhBSZKgTM

Kristi Anseth (BS '91, post doc '94) talks about her work in the field of tissue engineering as part of a series featuring some of the extraordinary people in Boulder, Colorado. Link: http://vimeo.com/57072055

More...

 


 

 

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