Laboratory Research

Our Laboratory of Biomaterials, Drug Delivery, Bionanotechnology and Molecular Recognition has been the leading group and pacesetter in the field of drug delivery and controlled release, a field that has been developed into a mature area of scholarly and applied research. In addition we have had extensive contributions in biomaterials and bionanotechnology, and have contributed seminal work in the field of feedback controlled biomedical devices. The multidisciplinary approach of this research in bionanotechnology and biomolecular engineering blends modern molecular and cellular biology with engineering to generate next-generation systems and devices, including bioMEMS with enhanced applicability, reliability, functionality, and longevity. Our contributions have been translated into more than twenty medical products with multibillion dollar markets.

Fundamentals of Biomedical and Pharmaceutical Transport Systems: The fundamentals and rational design of drug delivery systems and biomaterials have been set by our group over the past 35 years. In its very early days, drug delivery was an empirical field where the selection of components for successful formulations was based on a heuristic approach. Peppas and collaborators were the first to set the theories and equations that led to the design of a wide range of new systems. For example, using biomedical engineering principles and new biomedical transport theories, they developed the equations that describe Fickian and non-Fickian diffusion in controlled release devices. The “Peppas equation” has become the standard method of analysis of any pharmaceutical device. Using the modeling similarities of phase erosion and state erosion, they developed a unified models for all drug delivery systems. Similarly, they developed the theoretical framework for the analysis of transport through crosslinked biomaterials (the Peppas-Reinhart theory), ionic hydrogels (the Brannon-Peppas theory), and gel-tissue interactions via tethers (the Huang-Peppas theory and the Sahlin-Peppas equation). For the impact of these theories and analyses, Dr. Peppas has been recognized as the most cited and highly published author in drug delivery, biomaterials and drug delivery, and intelligent materials ( Web of Science ® 2012). He has also ranked as one of the most cited scientists with 65,690 citations (more than half of them in just the last five years) and an H-index of 124 (link) including nine contributions with more than 1,000 citations each.

Biomedical and Pharmaceutical Devices: Applications of these theories have had significant impact in the development of new biomedical systems and devices. Peppas and his students originated the novel muco- and bioadhesive systems that interact molecularly with the mucus and tissue and have been able to prolong bioavailability of proteins and peptides in the blood. As a result of his work, a number of biomedical polymers and commercial delivery devices have been launched. For example, our group was the first to develop novel toxic-free poly(vinyl alcohol) gels by the freezing-thawing technique in 1975. These gels became very successful articular cartilage replacement systems. In 1978, the group developed the same systems for in situ replacement of vocal cords, a successful medical procedure that remained in practice until the late 1990s and assisted about 45,000 patients.

Intelligent Hydrogels: This laboratory group pioneered (1979) the use of hydrogels in drug delivery applications, including epidermal bioadhesive systems and systems for the release of theophylline, proxyphylline, diltiazem, and oxprenolol. Perhaps the most important development of our labs has been the new technologies of oral delivery systems for insulin and other proteins. These devices release insulin orally, “protecting” the insulin throughout its transport in the stomach, upper small intestine, and, eventually, blood, and bypassing diabetics’ need for several daily injections. Dr. Peppas’ group has shown that these new systems exhibit very high bioavailability. This is the first time that an oral system has been shown to be effective for oral delivery of proteins, especially insulin. In fact, the same technology has been used for the transmucosal (oral, buccal) delivery of calcitonin (for treatment of osteoporosis in postmenopausal women) and interferon-alpha (for cancer therapy), and is presently investigated for interferon-beta release for multiple sclerotic patients. In tests on over 1500 rats and dogs that were given capsules containing microspheres of this new biomaterial carrier, high bioavailability was determined.

Intelligent, Feedback Control-Based Systems: Dr. Peppas was one of the pioneers of intelligent biomaterials, and medical devices. Using intelligent polymers as early as 1980, the Peppas group were the first to use such pH-sensitive and temperature-sensitive systems for modulated release of streptokinase and other fibrinolytic enzymes. In the 1990s and in this century, Dr. Peppas became the main proponent of the use of intelligent systems in the medical field. Physiologically-controlled and disease-responsive, feedback control-based devices require the operation/function of electrical and mechanical parts as a result of on-line measurement of physiological variables of the body, blood or other biological fluids. Peppas utilized the basics of biomedical transport phenomena, control theory, and kinetic behavior to design novel devices and to optimize their behavior in the body or in contact with the body. Adjustment of appropriate components of these devices was based on simple or sophisticated control or other physiological based models. To this end, Dr. Peppas and his group have investigated the biocompatibility of all components of these devices and have provided knowledge of cellular response mechanisms that may be related to changes in immunological status, physical tissue damage. Research in physiologically-responsive devices has sought to show how it is possible to use classical and biomedical engineering principles, mathematics, transport phenomena and control theory to design devices and artificial organs, often based on "intelligent materials," which are responsive to changes in the surrounding environment. Dr. Peppas developed feedback control devices, such as glucose-sensitive microsensors that can respond to abnormal glucose levels by releasing incorporated insulin to the blood at desired rates. Such feedback control systems could be perfected for use in treatment of diabetes. In addition, he developed temperature-sensitive devices that can be used for treatment of malaria by release of antipyretics. A natural consequence of this work was his founding of Mimetic Solutions, a company that commercializes these devices and is in the forefront of intelligent device and bioMEMs development.

1977-1990 1991-2000 2001-2006 2007-2013
Todd W.B Gehr Myung Cheon Lee Franco Barbato* Terry G. Farmer
Yen Bao* Christopher N. Bowman Yanbin Huang Lisa Lao*
Robert Gurny* Dukjoon Kim Petr Bures Irma Sanchez
Ming-Shin Yen Jennifer J. Sahlin Madeline Torres-Lugo Jeff Wilson
Lucy Lucht-Hair Atul R. Khare Hideki Ichikawa* Ruben Morones
Richard W. Korsmeyer Jianchu Wu William Leobandung Omar Fisher
Donald R. Miller Esmaiel Jabbari Aaron Foss Daniel Carr
Christian Bindschaedler Kristi Anseth Alexander Streubel Amber Doiron
G.W. Raymond Davidson III Deepak Hariharan  Bumsang Kim Justin Shofner
Serge Segot-Chicq Mary T. am Ende Sasa Baumgartner* Melissa A. Kanzelberger
Frederic Touchard Cristi L. Bell Ebru Oral Tania Betancourt*
Frederique Pothier-Lallemand J. Eric Dietz Marcos Garcia* Edgar Perez Herrero
Guillaume Conrath Devdatt L. Kurdikar Till Bussemer Carolyn Bayer
Bruno Gander Alessia deAscentis Cristina Donini Steve Marek
Christian Robert Ruggero Bettini Oya Sipahigil-Kerimoğlu Diana Snelling van Blarcom
Tae-Ho Kim* Balaji Narasimhan Mark Byrne Marta Gomez-Burgaz*
Hai-Shung Andy Tsou Surya Mallapragada Jay O. Blanchette Adam Ekenseair
Catherine Dubernet Christopher S. Brazel J. Zachary Hilt Martin L. Gran
M. Lisa Brannon Anthony M. Lowman David B. Henthorn Margaret Phillips-Gran
Ronald S. Harland Robert A. Scott Nikhil Kavimandan David Kryscio
Antonios G. Mikos Kairali Podual Nicole M. Bergmann Coro Echeverria
John Klier Christie M. Hassan-Bures Gianfranco Spizzirri* Cody Schoener
Steven Lustig Robert S. Parker Laura Serra Mar Creixell*
Mara Lovrecich* Jürgen Siepmann Elena Losi Eileen Dawson
Paolo Giunchedi* Mette Ingemann Kristy M. Wood William Liechty
Lauretta Maggi* Jing Zhang J. Brock Thomas Mary Caldorera-Moore*
Alec B. Scranton Jennifer Harting Ward E. Hunter Lauten Brenda Carrillo-Conde*
Olivier Saslawski   Donald E. Owens III  

* Green indicates those in academic positions
* Asterisk indicates former post docs

Celebration of the Founding of AICHE 100 Years Ago with article in the chemical heritage foundation magazine by Nicholas Peppas (Fall 2008) (click here)

PDF Version: Page 1 | Page 2

Photos of Students During NAP Tenure at Univ. of Texas

Profile of a husband and wife team: Nicholas and Lisa (PDF Version)

 

 


Video Presentations Featuring Lab Research


Current News

Nicholas A Peppas gave a short interview on how he decided to work on drug delivery and biomaterials problems and how he built his lab (link). At last count in his 38-year academic career, there have been 775 undergraduate and graduate students, postdocs and visiting scientists who have passed through the laboratory and worked on original research on drug delivery and related biomedical fields. They include almost 100 PhD graduates and 55 former graduate and postdoctoral researchers who are now faculty members.

Two papers published in the Journal of Controlled Release by P. Ritger and N. Peppas (link) and (link) are the most cited original papers in the 30-year history of the journal. A special article has been commissioned for this occasion for publication in JCR.

A paper from the lab, titled "An Inulin and Doxorubicin Conjugate for Improving Cancer Therapy" authored by Cody Schoener (ChE PhD'12, NSF Fellow), Brenda Carrillo-Conde (Post-doctoral fellow), Heather Hutson (BME BS'12, NSF Fellow at Univ. of Wisconsin-Madison) and Nicholas Peppas, won the 2013 best paper award of the Journal of Drug Delivery Science and Technology. The award will be given during the World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology in Lisbon on March 31- April 4 (link).

Professor Peppas was elected a Corresponding Member of the Academy of Athens (link, link in Greek, link in English). He will be inducted to the Academy and present an inaugural lecture on November 25, 2014 in the magnificent Academy building with the imposing statues of Socrates and Plato at its entrance.

A symposium in honor of Nicholas Peppas (link) was organized at the ACS meeting In Dallas, TX by his former PhD student and now distinguished professor at Colorado, Chris Bowman. The list of invited speakers included some of the leading names in macromolecular and biopolymer science including his former students Chris Bowman, Antonios Mikos, Kristi Anseth, John Klier and Balaji Narasimhan, his colleagues and/or collaborators Tom Truskett, Chris Ellison, Grant Willson and Ali Khademhosseini, and other friends and leading figures in the field such as Krzysztof Matyjasewski, Chad Mirkin, Sharon Glotzer, Matt Tirrell, Curt Frank, Sam Stupp, Joe DeSimone, Jindrich Kopecek and Buddy Ratner.

On March 6, Nicholas Peppas presented the Kammermeyer Lecture in the Department of Chemical and Biochemical Engineering of the University of Iowa (link)

Nicholas Peppas presented the 2014 Skalak Lecture in the Bioengineering Department of the University of California at San Diego on February 10, 2014 (link, link).

Nicholas Peppas presented an invited lecture on Molecular Imprinting and Recognitive Medical Devices at the University of Minho in Braga, Portugal (link).

Nicholas Peppas is featured in C&E News of January 6, 2014 on the occasion of the 2104 ACS Applied Polymer Science Award (link).

Additional News Items



Awarding of an honorary doctorate from the University of Ghent to Nicholas Peppas, March 1999 (in Flemish and English)

Awarding of an honorary doctorate by the University of Parma to Nicholas Peppas, October 1999 (in Italian)

Awarding of an honorary doctorate by the National and Capodistrian University of Athens, March 2000 (in Greek)

Ed Merrill seminar at MIT, 2001

KXAN Interview about Biomedical research, Austin, 2003

2003 SFB Founders' award: Ed Merrill

Nicholas Peppas gives the 2007 AIChE Institute Lecture

Tribute of NAP by Natalie Wisniewski, Austin, August 8, 2008

Tribute of NAP by Bob Langer, Austin, August 8, 2008

Tribute of NAP by Mike Sefton, Austin, August 8, 2008

Tribute of NAP by Kinam Park, Austin, August 8, 2008

Tribute of NAP by J Zach Hilt, Austin, August 8, 2008

Lisa Brannon-Peppas speaks about NAP, Austin, August 8, 2008

Nicholas Peppas thanks the participants of the 60th Birthday events, Austin, August 8, 2008

Celebration of Michael Sefton's 60th birthday with talks by Peppas and Sefton, Toronto, March 2009

Alan Michaels Lecture, MIT April 3, 2009

Liliane Bettencourt Seminar at College de France, Paris, March 2010 (in French)

Distinguished lecture, Merrill Symposium

Centennial lecture Purdue, October 2011

Inaugural speech upon induction to the National Royal Academy of Spain, March 2012 - Part 1

Inaugural speech upon induction to the National Royal Academy of Spain, March 2012 - Part 2

Nicholas Peppas welcoming speech at the 2012 World Biomaterials Congress

Nicholas Peppas presides to the induction ceremony of new IUSBSE Fellows at the 9th World Biomaterials Congress - Chengdu 2012

Some scenes from the 9th World Biomaterials Congress Closing Event – Chengdu 2012

NAE Founders Award, September 2012- Part 1

NAE Founders Award, September 2012- Part 2

National Academy of Engineering Founders Award Acceptance Speech, September 30, 2012

ASEE Interview of Nicholas Peppas by Les Benet of UCSF, AAPS meeting, Chicago, Oct 2012

Peppas talk on micro encapsulation in consumer and cosmetic products: Microencapsulation meeting, Pamplona Spain September 11, 2013

The Mission of a Biomedical Engineer, November 20, 2013

2014 ACS award in Applied Polymer Science

 

 

 

Fletcher Stuckey Pratt Chair in Engineering

Nicholas A. Peppas, Sc.D.
Departments of Chemical Engineering and Biomedical Engineering, and Division of Pharmaceutics
 
The University of Texas at Austin
1 University Station C0400
Austin, TX 78712-1062
peppas@che.utexas.edu

 

Recent Laboratory Publications

Click for Citations

1. N Annabi, A Tamayol, SR Shin, AM Ghaemmaghami, NA Peppas, Akhademhosseini, Surgical Materials: Current Challenges and Nano-enabled Solutions, Nano Today (under review).

2. M Caldorera-Moore, G Fletcher, K. Maas, NA Peppas, Hybrid Responsive Hydrogel Carriers for Oral Delivery of Hydrophobic, Low Molecular Weight Therapeutics, Cellul. Molec. Eng. (in press).

3. A Singh, NA Peppas, Hydrogels as scaffolds for immunomodulation, Adv. Mater. (accepted).

4. NA Peppas, B Narasimhan, Mathematical models in drug delivery: How modeling has shaped the way we design new drug delivery systems, J. Controlled Release, published on line, DOI: 10.1016/j.jconrel.2014.06.041 (link).

5. M Durán-Lobato, B Carrillo-Conde, Y Khairandish, NA Peppas, Surface-modified P(HEMA-co-MAA) Nanogel Carriers for Oral Vaccine Delivery: Design, Characterization, and Targeting Evaluation, Biomacromolecules, 15, 2725-2734 (2014) (link).

6. JM Knipe, F Chen, NA Peppas, Multi-responsive polyanionic microgels with inverse pH responsive behavior by encapsulation of polycationic nano gels, J Appl Polym Sci, published on line, DOI: 10.1002/app.40098 (link).

7. DC Forbes, NA Peppas, Polymeric Nanocarriers for siRNA Delivery to Murine Macrophages, Macromol Biosci., published on line, DOI: 10.1002/mabi.201400027 (link).

8. NA Peppas, Commentary on An Exponential Model for the Analysis of Drug Delivery, J. Controlled Release, (in press).

9. DC Forbes, NA Peppas, Polycationic Nanoparticles for siRNA Delivery: Comparing ARGET ATRP and UV-initiated Formulations, ACS Nano, 8, 2908-2917 (2014) (link).

10. H Culver, A Daily, A Khademhosseini, NA Peppas, Intelligent recognitive systems in nanomedicine, Curr. Opinion Chem. Engin., 4, 105-113 (2014) (link).

11. LA Sharpe, A Daily, S Horava and NA Peppas, Therapeutic applications of hydrogels in oral drug delivery. Exp. Opinion on Drug Delivery, 11, 901-915 (2014) (link).

12. MC Koetting and NA Peppas, pH-Responsive poly(itaconic acid-co-N-vinylpyrrolidone) hydrogels with reduced ionic strength loading solutions offer improved oral delivery potential for high isoelectric point-exhibiting therapeutic proteins, Intern. J. Pharmac., 471, 83-91 (2014) (link).

13. AK Gaharwar, NA Peppas, A Khademhosseini, Nanocomposite Hydrogels for Biomedical Applications, Biotechnology & Bioengineering, under revision. 111, 441-453 (2014) (link).

14. NA Peppas, ME Caldorera-Moore, and SD Steichen, Historical survey of drug delivery devices, in R Siegel and SP Lyu, eds, Drug-Device Combinations for Chronic Diseases, Wiley, New York, NY, in press.

15. N Annabi, A Tamayol, JA Uquillas, M Akbari, L Bertassoni, C Cha, G Camci-Unal, M Dokmeci, NA Peppas and A Khademhosseini, Emerging Frontiers in Rational Design and Application of Hydrogels in Regenerative Medicine, Adv. Materials, 26, 85-124 (2014) (link).

16. D Forbes; NA Peppas, "Differences in molecular structure in cross-linked polycationic nanoparticles synthesized using ARGET ATRP or UV-initiated polymerization", Polymer 54, 4486-4492 (2013) (link).

17. WB Liechty; RL Scheuerle; NA Peppas, "Tunable, responsive nanogels containing tert-butyl methacrylate and 2-(tert-butylamino)ethyl methacrylate", Polymer 54, 3784-3795 (2013) (link).

18. Schoener C A; Carillo-Conde B; Hutson H N; and Peppas N A, An Inulin and Doxorubicin Conjugate for Improving Cancer Therapy, J. Drug Deliv. Sci. Technol. 23, 111-118 (2013) (link).

19. Schoener C A; Hutson H N; Peppas N A, Amphiphilic Interpenetrating Polymer Networks for the Oral Delivery of Chemotherapeutics, AIChE J. 59, 1472-1478 (2013) (link).

20. J. M. Knipe, J.T. Peters and N. A. Peppas, “Theranostic agents for gene delivery and spatiotemporal tracking", NanoToday, 8, 21-38 (2013) (link).

Other recent publications


PubMed Search (for more recent publications including the texts)

Peppas, Nicholas
Peppas, Nicholas A
Peppas, N


National Distinctions of Laboratory Graduates


 

Other Important videos from the lab and some of its graduates:

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