Publications

2012-2013 2010-2011 Prior to 2010  

2013

  • 211.     Paley, O., Agnello, G., Cantor, J., Yoo, T.H., Georgiou, G., Stone E.M., “GFP Reporter Screens for the Engineering of Amino Acid Degrading Enzymes from Libraries Expressed in Bacteria,” Methods Mol. Biol. 978:31-44 (2013) PMID: 23423887

    210.     DeKosky, B.J., Ippolito, G.C., Deschner, R.P., Lavinder, J.J., Rawlings, M.P., Varadarajan, N., Wine, Y., Giesecke, C., Dörner, T., Andrews, S.F., Wilson, P.C., Hunicke-Smith, S.P., Wilson, C.P., Ellington, A.D. and G. Georgiou, “High Throughput Determination of the Antibody VH:VL Paired Repertoires,” Nature Biotechnol. 31:166-69(2013) PMID: 23334449

    209.     Needham, B.D., Carroll, S., Giles, D.K., Georgiou, G., Whiteley, M., and Trent, M.S.  “Modulating the Innate Immune Response by Combinatorial Engineering of Endotoxin” Proc. Natl. Acad. Sci. USA 110:1464-69 (2013) PMID: 23297218
     Commentaries Science: http://stm.sciencemag.org/content/5/170/170ec20.full; The Scientist:
    http://www.the-scientist.com//?articles.view/articleNo/34313/title/Bacteria-Boost-Vaccine-Effectiveness/
     Selected as a “Recommended” paper: http://f1000.com/prime/717982098#recommendations

    208.     Wine, Y., Boutz, D., Lavinder, J.J., Horton, A., Miklos, A.E., Hughes, R.A., Jung, S.T, Murrin E.M., Ellington, A.D., Marcotte, E.M. and G. Georgiou,  “Molecular Deconvolution of the Monoclonal Antibodies that Comprise the Polyclonal Serum Response,” Proc. Natl. Acad. Sci. USA 110: 2993-8(2013) PMID: 23382245

    207.Carroll, S. and G. Georgiou,“Antibody-Mediated Inhibition of Human C1s and the Classical Complement Pathway, “ Immunobiology doi:pii: S0171-2985(13)00006-5. 10.1016/j.imbio.2013.01.001 (2013). 

    206.     Mittal, J., Yoo, T-H., Georgiou, G. and T.M. Truskett, “Structural Ensemble of an Intrinsically Disordered Polypeptide” J Phys Chem B. 117:118-24 (2013) PMID: 23205890

    205.     Jung, S. T., Kelton, W., Kang, T. H.; Ng, D., Anderssen, J. T.; Sandlie, I., Sarkar, C., G. Georgiou,
    "Effective Phagocytosis of Low Her2 Tumor Cell Lines with Engineered, Aglycosylated IgG Displaying High FcγRIIa Affinity and Selectivity" ACS Chem. Bio. 8:368-75 (2013) PMID: 23030766

2012

  • Saggy, I., Wine, Y., Georgiou G. and Benhar, I., "Antibody Isolation from Immunized Animals: Comparison of Phage Display and Antibody Discovery via V gene Repertoire Mining" PEDS (2012) PMID: 22988130
  • Stone, E.M., Paley, O., Hu, J., Ekerdt, B.; Cheung, N.-K. and G., George, "De novo Engineering of a Human Methionine-γ-Lyase for Systemic L-Met Depletion Cancer Therapy," ACS Chem. Bio. (2012) PMID: 22963240
    Commentary in Chem & Eng News
  • Romero, P.A., Stone, E.M., Lamb, C., Chantranupong, L., Krause, A., Miklos, A.E., Hughes, R.A., Fechtel, B., Ellington, D.A., Arnold, F.H. and G. Georgiou, "SCHEMA-Designed Variants of Human Arginase I and II Reveal Sequence Elements Important to Stability and Catalysis", ACS Synth. Biol. 1:221-28 (2012) PMID: 22737599
  • Li W., Cantor, J., Yogesha, S.D.,  Yang, S., Chantranupong, L., Liu, J.Q., Agnello, G., G. Georgiou, Stone E.M.,  and Y. Zhang,“Uncoupling Intramolecular Processing and Substrate Hydrolysis in the N-terminal Hydrolase hASRGL1 by Circular Permutation" ACS Chem. Bio. Epub ahead of print (2012) PMID: 22891768
  • Borrok, J.M., Jung, S.T., Kang, T.H. ; Monzingo, A. and G. Georgiou, Revisiting the Role of Glycosylation
    in the Structure of Human IgG Fc"  ACS Chem. Bio (2012) PMID: 22747430
  • Rani, M., Bolles, M., Donaldson, E.F., Van Blarcom, T.,  Baric, R., Iverson, B.L. and G. Georgiou “Increased Antibody Affinity Confers Broad In Vitro Protection Against Escape Mutants of SARS-CoV”  J. Virology 86:9113-21 (2012)  PMID: 2269665
  • Skretas, G.  Makino, T. Varadarajan N.,  Pogson M. and G. Georgiou,  “Multi-Copy Genes that Enhance the Yield of Mammalian G Protein-Coupled Receptors in Escherichia coliMetabolic Eng. 14:591-602 (2012) PMID: 22609824 
  • Mauldin, J.P., Zeinali, I., Kleypas, K., Woo, J.H., Blackwood, R.S., Jo, C.H., Stone, E.M., Georgiou G., Frankel A. E., Transl. Oncology 5:26-31 (2012) PMID: 22348173
  • Ippolito, G.C.,  Hoi K.H., Reddy S.T., Carroll S.M., Ge X., Rogosch T., Zemlin M., Shultz L.D., Ellington A.D., Vandenberg C.L., and G. Georgiou, “Antibody Repertoires in Humanized NOD-scid-IL2Rγnull Mice
    and Human B Cells Reveals Human-like Diversification and Tolerance Checkpoints in the Mouse” PLoS One 7:e35497 (2012) PMID: 2255816
  • Miklos, A.E., Kluwe, C., Der. B.S., Pai, S., Sircar, A., Hughes, R.A., Berrondo, M., Xu, J., Codrea, V., Buckley,
    P.E., Calm, A.M., Walsh, H.S., Warner, C.R., Zacharko, M.A., Carney, J.P., Georgiou, G., Kuhlman, B. and A.D. Ellington,  “Structure-Based Design of Supercharged, Highly Thermostable Antibodies,”  Chem. & Biol.  19:449-55 (2012) PMID: 22520751
  • Yoo, T-H., Pogson, M., Iverson, B.L. and G. Georgiou,  "Directed Evolution of Highly Selective Proteases Using a Novel FACS Based Screen that Capitalizes on the p53 Regulator MDM2" ChemBiochem 3:649-53(2012) PMID: 22334509
  • Cantor,  J.R., Panayotou, V., Agnello, G., Stone. E.M. and G. Georgiou, “Engineering Reduced Immuno--genicity Enzymes for Amino Acid Depletion Therapy in Cancer,”  Methods Enzymol. 502:291-312 (2012). PMID:22208990
  • Agrawal, V., Boyer, A.L., Woo, J-H., Mauldin,J.P., Chanhee, J. Stone, E.M., Georgiou, G. and Arthur E. Frankel, " Cytotoxicity of Human Recombinant Arginase I [Co] PEG5000 in the Presence of L-Citruline is Dependent on Arginosuccinate Synthetase Expression in Human Cells"Anti-Cancer Drugs 23:51-64 (2012)PMID:21955999
  • Stone, E. M., Chantrranupong L., Gonzalez, C., O’Neal, J., Rani, M., VanDenBerg, C. and G. Georgiou, "Strategies for Optimizing the Serum Persistence of Engineered Human Arginase I for Cancer Therapy," J. Control. Release 58L171-9 (2012) PMID 22001609.