The Georgiou Lab is currently working primarily on the discovery and development of protein therapeutics and applied immunology by capitalizing on state of the art protein engineering, directed evolution and systems biology technologies.
- The Engineering of human therapeutic enzymes for the treatment of a variety of malignancies.
- Deconvolution of antibody responses and antibody signatures in disease states.
- Engineering and optimization of therapeutic antibodies.
- Design of proteolytic enzymes that cleave and irreversibly inactivate disease targets.
In parallel, our lab has been working for over 20 years on redox homeostasis, disulfide bond formation and protein biogenesis in bacteria, with current projects related to:
- Evolution of novel pathways for rewiring electron transfer in E.coli.
- Dissecting the role of LMW thiols in redox homeostasis and cell physiology.
Some of the latest research: