George Georgiou Research Group

 

Sang Taek Jung

Academic Background

B.S., Seoul National University, Seoul, Korea (1997)

M.S., Seoul National University, Seoul, Korea (1999)

Currently: Ph.D. student, Dept. of Chemical Engineering, University of Texas at Austin (Aug. 2004 – present) 

 

 

Research Description

Antibody Fc Engineering Using Bacterial Display System. Fc region of IgG is responsible for antibody effector functions including antibody dependent cell mediated cytotocicity (ADCC), complement dependent cytotocicity (CDC), and serum stability by binding to Fcγ receptors, C1q, and FcRn, respectively. My research is focused on engineering of the Fc to enhance the antibody effector functions using bacterial combinatorial display technique and high throughput FACS screening system.Additionally, I am working to employ the Anchored Periplasmic Expression (APEx) technology for the screening of libraries based on binding to insoluble antigens from large repertoire libraries possibly including antigens on cell surfaces.  

 

Publications 

  1. Jung, S. T., Jeong, K. J., Iverson, B. L. and Georgiou, G. (2007) Biotechnol Bioeng 98, 39-47 (Spotlight in the issue)

  2. Kim, M. S., Kim, S. S., Jung, S. T., Park, J. Y., Yoo, H. W., Ko, J., Csizar, K., Choi, S. Y., and Kim, Y. (2003) J Biol Chem 278 (52), 52071-52074

  3. Jung, S. T., Kim, M. S., Seo, J. Y., Kim, H. C. and Kim, Y. (2003) Protein Expr Purif 31 (2), 240-246

  4. Kang, S. H., Jung, S. T., Kang, T. J., Kim, R. G., Suh, S. H., Woo, J. H., Lee, E. Y., and Choi, C. Y. (1999) Biotechnol Techniques 13, 761-764

  5. Kang, T. J., Kang, S. H., Jung, S. T., Lee, E. Y., and Choi, C. Y. (1999) J  Biosci Bioeng 88(3), 345-347

Last updated 04/09/2008