Cockrell School of Engineering Lectureship
Seminar Abstract:
The pathological hallmark of more than twenty neurodegenerative diseases, like Alzheimer’s, Parkinson’s and the prion diseases, is the presence within the brain of plaques containing ordered protein aggregates called fibrils. It is not yet known why these structures form in some individuals and not in others, or whether the plaques are toxic or Nature’s way of sequestering toxic species. Dr. Hall will describe current thinking on the scientific underpinnings for this phenomenon, and her computational efforts to contribute to our knowledge of how and why proteins assemble into fibrils.